Protein Family Models

This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein [1]. [1]. 10464210. Role of the sporulation protein BofA in regulating activation of. the Bacillus subtilis developmental transcription factor sigmaK.. Resnekov O;. J Bacteriol 1999;181:5384-5388. (from Pfam)

Date:

2024-08-14

Gene:

bofA

Date:

2020-12-30

Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K.

Gene:

bofA

Date:

2021-04-27

pro-sigmaK processing inhibitor BofA family protein similar to Bacillus subtilis sigma-K factor-processing regulatory protein BofA that is involved in the mediation of the intercompartmental coupling of pro-sigma K processing to events in the forespore

Date:

2020-05-06