Protein Family Models

YoeB_toxin is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in Pfam:PF02604. The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth [1]. These toxins are highly potent protein synthesis inhibitors, specifically blocking the initiation of translation. In the case of YoeB, it binds to the 50 S ribosomal subunit in 70 S ribosomes and interacts with the A site leading to mRNA cleavage at this site. As a result, the 3'-end portion of the mRNA is released from ribosomes, and translation initiation is effectively inhibited [2,3]. [1]. 12603745. Axe-Txe, a broad-spectrum proteic toxin-antitoxin system. specified by a multidrug-resistant, clinical isolate of. Enterococcus faecium.. Grady R, Hayes F;. Mol Microbiol 2003;47:1419-1432.. [2]. 17170003. Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB. with paired DNA palindromes exerts transcriptional. autorepression.. Kedzierska B, Lian LY, Hayes F;. Nucleic Acids Res. 2007;35:325-339.. [3]. 19124462. The inhibitory mechanism of protein synthesis by YoeB, an. Escherichia coli toxin.. Zhang Y, Inouye M;. J Biol Chem. 2009;284:6627-6638. (from Pfam)

Date:

2024-08-14