Protein Family Models

This domain is found in NifU in combination with Pfam:PF01106. This domain is found on isolated in several bacterial species such as Swiss:O53156. The nif genes are responsible for nitrogen fixation. However this domain is found in bacteria that do not fix nitrogen, so it may have a broader significance in the cell than nitrogen fixation. These proteins appear to be scaffold proteins for iron-sulfur clusters [2]. [1]. 8875867. A modular domain of NifU, a nitrogen fixation cluster protein,. is highly conserved in evolution.. Hwang DM, Dempsey A, Tan KT, Liew CC;. J Mol Evol 1996;43:536-540.. [2]. 12970193. Components involved in assembly and dislocation of iron-sulfur. clusters on the scaffold protein Isu1p.. Muhlenhoff U, Gerber J, Richhardt N, Lill R;. EMBO J 2003;22:4815-4825. (from Pfam)

Date:

2024-08-14

Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. SUF is important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents SufU from the SUF system, a homolog of IscU and NifU. It is now understood to be a sulfur transfer protein, although previously it was called a scaffold protein.

Gene:

sufU

Date:

2024-03-04