Protein Family Models for Protein (Select 491817717) - Protein Family Models

Select item 3968241.

L-fucose isomerase, second N-terminal domain

The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta- sheets with surrounding alpha helices. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting residues [1]. [1]. 9367760. Structure and mechanism of L-fucose isomerase from Escherichia. coli.. Seemann JE, Schulz GE;. J Mol Biol 1997;273:256-268. (from Pfam)

GO Terms:

Cellular Component:: cytoplasm (GO:0005737)

Biological Process:: fucose metabolic process (GO:0006004)

Molecular Function:: L-fucose isomerase activity (GO:0008736)

Date:: 2024-04-03

Family Accession:: NF019497.4
Method:: HMM

Select item 3949232.

L-fucose isomerase, first N-terminal domain

The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta-sheets with surrounding alpha helices. Domain 1 demonstrates the beta-alpha-beta-alpha- beta Rossman fold. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting residues, and domain 1 from the adjacent subunit contributing some other residues [1]. [1]. 9367760. Structure and mechanism of L-fucose isomerase from Escherichia. coli.. Seemann JE, Schulz GE;. J Mol Biol 1997;273:256-268. (from Pfam)

GO Terms:

Cellular Component:: cytoplasm (GO:0005737)

Biological Process:: fucose metabolic process (GO:0006004)

Molecular Function:: L-fucose isomerase activity (GO:0008736)

Date:: 2024-04-03

Family Accession:: NF019496.4
Method:: HMM

Select item 3911243.

L-fucose isomerase, C-terminal domain

GO Terms:

Cellular Component:: cytoplasm (GO:0005737)

Biological Process:: fucose metabolic process (GO:0006004)

Molecular Function:: L-fucose isomerase activity (GO:0008736)

Date:: 2023-12-12

Family Accession:: NF014948.4
Method:: HMM

Select item 3539454.

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Select item 3519375.

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Family Accession:

Select item 3492296.

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Select item 3229467.

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Select item 3219968.

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Select item 3198799.

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Select item 15444410.

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Select item 15444311.

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Select item 15433512.

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Select item 15433413.

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Select item 5987014.

L-fucose isomerase

L-fucose isomerase catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose

Date:: 2018-02-26

Family Accession:: 11485139
Method:: Sparcle

Select item 2575415.

L-fucose isomerase

This enzyme catalyzes the first step in fucose metabolism, and has been characterized in Escherichia coli and Bacteroides thetaiotaomicron.

Gene:: fucI

GO Terms:

Biological Process:: L-fucose biosynthetic process (GO:0006005)

Molecular Function:: L-fucose isomerase activity (GO:0008736)

Date:: 2021-04-27

Family Accession:: TIGR01089.1
Method:: HMM

Select item 2448816.

L-fucose isomerase

Catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose

GO Terms:

Biological Process:: monosaccharide metabolic process (GO:0005996)

Molecular Function:: L-fucose isomerase activity (GO:0008736)

Biological Process:: fucose catabolic process (GO:0019317)

Molecular Function:: manganese ion binding (GO:0030145)

Date:: 2021-10-04

Family Accession:: NF008220.0
Method:: HMM

Select item 636717.

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Select item 575518.

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