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CodY helix-turn-helix domain
This family consists of the C-terminal helix-turn-helix domain found in several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2]. [1]. 7783641. A gene required for nutritional repression of the Bacillus. subtilis dipeptide permease operon.. Slack FJ, Serror P, Joyce E, Sonenshein AL;. Mol Microbiol 1995;15:689-702.. [2]. 11401725. Pleiotropic transcriptional repressor CodY senses the. intracellular pool of branched-chain amino acids in Lactococcus. lactis.. Guedon E, Serror P, Ehrlich SD, Renault P, Delorme C;. Mol Microbiol 2001;40:1227-1239. (from Pfam)
CodY GAF-like domain
This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. This domain is involved in GTP binding and also branched chain amino acids (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2]. [1]. 7783641. A gene required for nutritional repression of the Bacillus. subtilis dipeptide permease operon.. Slack FJ, Serror P, Joyce E, Sonenshein AL;. Mol Microbiol 1995;15:689-702.. [2]. 11401725. Pleiotropic transcriptional repressor CodY senses the. intracellular pool of branched-chain amino acids in Lactococcus. lactis.. Guedon E, Serror P, Ehrlich SD, Renault P, Delorme C;. Mol Microbiol 2001;40:1227-1239. (from Pfam)
GTP-sensing pleiotropic transcriptional regulator CodY
GTP-sensing pleiotropic transcriptional regulator CodY is a DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation
This model represents the full length of CodY, a pleiotropic repressor in Bacillus subtilis and other Firmicutes (low-GC Gram-positive bacteria) that responds to intracellular levels of GTP and branched chain amino acids. The C-terminal helix-turn-helix DNA-binding region is modeled by PF08222 in Pfam.
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