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EI24 domain-containing protein
This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53 [1]. It has been suggested to play an important role in negative cell growth control [2]. [1]. 8649819. Identification and cloning of EI24, a gene induced by p53 in. etoposide-treated cells.. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC;. Oncogene 1996;12:1181-1187.. [2]. 10594026. ei24, a p53 response gene involved in growth suppression and. apoptosis.. Gu Z, Flemington C, Chittenden T, Zambetti GP;. Mol Cell Biol 2000;20:233-241. (from Pfam)
sulfate transporter CysZ
CysZ is a high affinity, high specificity proton-dependent sulfate transporter which mediates sulfate uptake by providing the sulfur source for the cysteine biosynthesis pathway
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