Protein Family Models

This entry includes a group of putative nuclease, including hypothetical protein TT1808 (also known as Uma2 or TTHA1514), an AT-rich DNA-binding protein from Thermus thermophilus. This domain has a 3-layer alpha/beta/alpha topology similar to that found in restriction endonucleases [1]. The nuclease domain is ubiquitously found in enzymes involved in metabolism of nucleic acids, mostly in nucleases with diverse biological functions [2]. [1]. 17154156. Crystal structure of TTHA1657 (AT-rich DNA-binding protein; p25). from Thermus thermophilus HB8 at 2.16 A resolution.. Nakamura A, Sosa A, Komori H, Kita A, Miki K;. Proteins. 2007;66:755-759.. [2]. 15720711. Identification of a new family of putative PD-(D/E)XK nucleases. with unusual phylogenomic distribution and a new type of the. active site.. Feder M, Bujnicki JM;. BMC Genomics. 2005;6:21-21. (from Pfam)

Date:

2024-08-14

Uma2 family endonuclease belongs to the PDDEXK nuclease superfamily and may act as a restriction endonuclease

Date:

2022-08-17