Protein Family Models

This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes ([1]). It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni FtsH is involved in protection against environmental stress ([2]), and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear. [1]. 12667449. Lack of a robust unfoldase activity confers a unique level of. substrate specificity to the universal AAA protease FtsH.. Herman C, Prakash S, Lu CZ, Matouschek A, Gross CA;. Mol Cell 2003;11:659-669.. [2]. 12732516. The ftsH gene of the wine bacterium Oenococcus oeni is involved. in protection against environmental stress.. Bourdineaud JP, Nehme B, Tesse S, Lonvaud-Funel A;. Appl Environ Microbiol 2003;69:2512-2520. (from Pfam)

Date:

2024-08-14

ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein such as ATP-dependent zinc metalloprotease FtsH, which targets both cytoplasmic and membrane proteins and plays a role in quality control of integral membrane proteins

Date:

2017-03-02