Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
transaldolase family protein
Transaldolase (TAL) is an enzyme of the pentose phosphate pathway (PPP) found almost ubiquitously in the three domains of life (Archaea, Bacteria, and Eukarya). TAL shares a high degree of structural similarity and sequence identity with fructose-6-phosphate aldolase (FSA). They both belong to the class I aldolase family[4]. Their protein structures have been revealed[5]. [1]. 11705376. Snapshots of catalysis: the structure of. fructose-1,6-(bis)phosphate aldolase covalently bound to the. substrate dihydroxyacetone phosphate.. Choi KH, Shi J, Hopkins CE, Tolan DR, Allen KN;. Biochemistry 2001;40:13868-13875.. [2]. 11298760. Identification of catalytically important residues in the active. site of Escherichia coli transaldolase.. Schorken U, Thorell S, Schurmann M, Jia J, Sprenger GA,. Schneider G;. Eur J Biochem 2001;268:2408-2415.. [3]. 10869557. The three-dimensional structure of human transaldolase.. Thorell S, Gergely P Jr, Banki K, Perl A, Schneider G. FEBS Lett 2000;475:205-208.. [4]. 26131847. Converting Transaldolase into Aldolase through Swapping of the. Multifunctional Acid-Base Catalyst: Common and Divergent. Catalytic Principles in F6P Aldolase and Transaldolase.. Sautner V, Friedrich MM, Lehwess-Litzmann A, Tittmann K;. Biochemistry. 2015;54:4475-4486.. [5]. 25267444. Sweet siblings with different faces: the mechanisms of FBP and. F6P aldolase, transaldolase, transketolase and phosphoketolase. revisited in light of recent structural data.. Tittmann K;. Bioorg Chem. 2014;57:263-280. (from Pfam)
transaldolase family protein such as transaldolase, which is important for the balance of metabolites in the pentose-phosphate pathway and catalyzes the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate, or fructose-6-P aldolase, which catalyzes an aldol cleavage of fructose 6-phosphate
fructose-6-phosphate aldolase
This HMM represents a family that includes the E. coli transaldolase homologs TalC and MipB, both shown to be fructose-6-phosphate aldolases rather than transaldolases as previously thought. It is related to but distinct from the transaldolase family of E. coli TalA and TalB. The member from Bacillus subtilis becomes phosphorylated during early stationary phase but not during exponential growth.
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on