Protein Family Models for Protein (Select 497303993) - Protein Family Models

Warning: The NCBI web site requires JavaScript to function. more...

Links from Protein

Items: 6

Select item 4296581.

Stability determinant

Date:: 2024-08-14

Family Accession:: NF045321.2
Method:: HMM

Select item 4144332.

type II toxin-antitoxin system RelB/DinJ family antitoxin

RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes ([1], [2]). RelB stably binds RelE, presumably deactivating it. [1]. 11274135. Purification of the RelB and RelE proteins of Escherichia coli:. RelE binds to RelB and to ribosomes.. Galvani C, Terry J, Ishiguro EE;. J Bacteriol 2001;183:2700-2703.. [2]. 12123459. Rapid induction and reversal of a bacteriostatic condition by. controlled expression of toxins and antitoxins.. Pedersen K, Christensen SK, Gerdes K;. Mol Microbiol 2002;45:501-510. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF016136.5
Method:: HMM

Select item 4083223.

new record, indexing in progress

Family Accession:

Select item 3910034.

new record, indexing in progress

Family Accession:

Select item 3508395.

new record, indexing in progress

Family Accession:

Select item 492466.

type II toxin-antitoxin system RelB/DinJ family antitoxin

Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than Pfam model PF04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species.

GO Terms: