Protein Family Models

This is sensor domain found in bacterial periplasmic binding proteins, several of which are involved in iron and cobalamin transport [1,2,3]. Among its ligands are siderophores bacillibactin, enterobactin and iron(III)-hydroxamates (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043). [1]. 2651410. Nucleotide sequences of the fecBCDE genes and locations of the. proteins suggest a periplasmic-binding-protein-dependent. transport mechanism for iron(III) dicitrate in Escherichia coli.. Staudenmaier H, Van Hove B, Yaraghi Z, Braun V;. J Bacteriol 1989;171:2626-2633.. [2]. 12475936. The structure of Escherichia coli BtuF and binding to its. cognate ATP binding cassette transporter.. Borths EL, Locher KP, Lee AT, Rees DC;. Proc Natl Acad Sci U S A. 2002;99:16642-16647.. [3]. 14514690. The role of FhuD2 in iron(III)-hydroxamate transport in. Staphylococcus aureus. Demonstration that FhuD2 binds. iron(III)-hydroxamates but with minimal conformational change. and implication of mutations on transport.. Sebulsky MT, Shilton BH, Speziali CD, Heinrichs DE;. J Biol Chem. 2003;278:49890-49900. (from Pfam)

Date:

2024-08-14

siderophore ABC transporter substrate-binding protein such as Bacillus subtilis petrobactin-binding protein YclQ, which is part of the ABC transporter complex YclNOPQ involved in uptake of ferric-petrobactin, a photoreactive 3,4-catecholate siderophore, and which selectively binds iron-free and ferric petrobactin and the petrobactin precursor 3,4-dihydroxybenzoic acid

Date:

2018-07-10