Protein Family Models

Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9. [1]. 9200602. Properties of H. volcanii tRNA intron endonuclease reveal a. relationship between the archaeal and eucaryal tRNA intron. processing systems.. Kleman-Leyer K, Armbruster DW, Daniels CJ;. Cell 1997;89:839-847.. [2]. 9535656. Crystal structure and evolution of a transfer RNA splicing. enzyme.. Li H, Trotta CR, Abelson J;. Science 1998;280:279-284. (from Pfam)

Date:

2024-08-14

Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9. [1]. 9200602. Properties of H. volcanii tRNA intron endonuclease reveal a. relationship between the archaeal and eucaryal tRNA intron. processing systems.. Kleman-Leyer K, Armbruster DW, Daniels CJ;. Cell 1997;89:839-847.. [2]. 9535656. Crystal structure and evolution of a transfer RNA splicing. enzyme.. Li H, Trotta CR, Abelson J;. Science 1998;280:279-284.. [3]. 22638584. Sequence, structure and functional diversity of PD-(D/E)XK. phosphodiesterase superfamily.. Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski. K;. Nucleic Acids Res. 2012;40:7016-7045. (from Pfam)

Date:

2024-08-14

SEN2 family protein

Date:

2017-03-02

The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini. The genes are homologous in Eucarya and Archea. The two yeast genes have been functionally studied (see MEDLINE; 97344075) and are two subunits of a heterotetramer enzyme in yeast the other two subunits of which have no known homologs.

Gene:

endA

Date:

2024-06-27