Protein Family Models

This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity [1]. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain [2]. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important. [1]. 8063411. Cloning, sequencing, and expression of a. fibronectin/fibrinogen-binding protein from group A. streptococci.. Courtney HS, Li Y, Dale JB, Hasty DL;. Infect Immun 1994;62:3937-3946.. [2]. 24646681. A highly conserved family of domains related to the. DNA-glycosylase fold helps predict multiple novel pathways for. RNA modifications.. Burroughs AM, Aravind L;. RNA Biol. 2014;11:360-372. (from Pfam)

Date:

2024-08-14

This HMM contains the N-terminal and central domains of NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. Many members of this family from eukaryotes, archaea, and bacteria act in ribosome quality control (RQC), including RqcH, shown to help add a poly-Ala tail to abortively translated proteins to tag them for degradation. This process is analogous to and partial redundant with the ssrA/tmRNA system. However, some other NFACT family members, such as bacterial proteins FbpA in Listeria or PavA in Streptococcus, are exported (despite lack of a classical signal peptide) and behave as fibronectin-binding adhesins associated with virulence.

Date:

2024-08-14

This HMM (built with support from arCOG01695) describes archaeal homologs of the RqcH (Ribosome-associated Quality Control H), involved in release of defective mRNAs that lack a stop codons and so are stuck on ribosomes. Conservation of a role in ribosome rescue for this archaeal family is supported by presence in a conserved gene neighborhood with homologs of Pelota/Dom34 and ABCE1/Rli1 homologs, proteins involved in splitting the ribosome into large and small subunits.

Gene:

rqcH

Date:

2022-08-30

NFACT family protein containing a DUF814 domain, may act in ribosome quality control (RQC) by adding a poly-Ala tail to abortively translated proteins to tag them for degradation, or be exported and behave as a fibronectin-binding adhesin associated with virulence

Date:

2021-02-02