Protein Family Models

This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyses the addition of O-GlcNAc to serine and threonine residues [1,2]. In addition to its function as an O-GlcNAc transferase, human OGT, Swiss:O15294, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1 [3]. [1]. 18818698. Structural insights into mechanism and specificity of O-GlcNAc. transferase.. Clarke AJ, Hurtado-Guerrero R, Pathak S, Schuttelkopf AW,. Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM;. EMBO J. 2008;27:2780-2788.. [2]. 18536723. Structure of an O-GlcNAc transferase homolog provides insight. into intracellular glycosylation.. Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ,. Davies GJ;. Nat Struct Mol Biol. 2008;15:764-765.. [3]. 21295698. O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of. HCF-1.. Capotosti F, Guernier S, Lammers F, Waridel P, Cai Y, Jin J,. Conaway JW, Conaway RC, Herr W;. Cell. 2011;144:376-388. (from Pfam)

Date:

2024-08-14

Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis [1][2]. [1]. 9515923. Characterization of the gene cassette required for biosynthesis. of the (alpha1-->6)-linked N-acetyl-D-mannosamine-1-phosphate. capsule of serogroup A Neisseria meningitidis.. Swartley JS, Liu LJ, Miller YK, Martin LE, Edupuganti S,. Stephens DS;. J Bacteriol. 1998;180:1533-1539.. [2]. 11953367. Novel Aeromonas hydrophila PPD134/91 genes involved in O-antigen. and capsule biosynthesis.. Zhang YL, Arakawa E, Leung KY;. Infect Immun. 2002;70:2326-2335. (from Pfam)

Date:

2024-08-14

Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis [1][2]. [1]. 9515923. Characterization of the gene cassette required for biosynthesis. of the (alpha1-->6)-linked N-acetyl-D-mannosamine-1-phosphate. capsule of serogroup A Neisseria meningitidis.. Swartley JS, Liu LJ, Miller YK, Martin LE, Edupuganti S,. Stephens DS;. J Bacteriol. 1998;180:1533-1539.. [2]. 11953367. Novel Aeromonas hydrophila PPD134/91 genes involved in O-antigen. and capsule biosynthesis.. Zhang YL, Arakawa E, Leung KY;. Infect Immun. 2002;70:2326-2335. (from Pfam)

Date:

2024-08-14

Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids. (from Pfam)

Date:

2024-08-14