Protein Family Models

Date:

2024-08-14

This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system. (from Pfam)

Date:

2024-08-14

The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. The Rad50 coiled-coil region contains a dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn ion. This alignment includes the zinc hook motif and a short stretch of coiled-coil on either side. [1]. 12152085. The Rad50 zinc-hook is a structure joining Mre11 complexes in. DNA recombination and repair.. Hopfner KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BA,. Karcher A, Henderson B, Bodmer JL, McMurray CT, Carney JP,. Petrini JH, Tainer JA;. Nature 2002;418:562-566.. [2]. 12151226. Tethering on the brink: the evolutionarily conserved Mre11-Rad50. complex.. Connelly JC, Leach DR;. Trends Biochem Sci 2002;27:410-418. (from Pfam)

Date:

2024-08-14

This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination. [1]. 10429180. Structural maintenance of chromosomes (SMC) proteins: conserved. molecular properties for multiple biological functions.. Strunnikov AV, Jessberger R;. Eur J Biochem 1999;263:6-13.. [2]. 9640531. SMC protein complexes and higher-order chromosome dynamics.. Hirano T;. Curr Opin Cell Biol 1998;10:317-322. (from Pfam)

Date:

2024-08-14

Involved in DNA double-strand break repair (DSBR); rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity; Rad50 provides an ATP-dependent control of mre11 by unwinding and/or repositioning DNA ends into the mre11 active site

Gene:

rad50

Date:

2022-07-22

protein similar to DNA double-strand break repair Rad50 ATPase

Date:

2017-03-02