Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
AAA family ATPase
This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. (from Pfam)
SMC proteins Flexible Hinge Domain
This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction ([1]). [1]. 12411491. Hinge-mediated dimerization of SMC protein is essential for its. dynamic interaction with DNA.. Hirano M, Hirano T;. EMBO J 2002;21:5733-5744. (from Pfam)
RecF/RecN/SMC N terminal domain
This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination. [1]. 10429180. Structural maintenance of chromosomes (SMC) proteins: conserved. molecular properties for multiple biological functions.. Strunnikov AV, Jessberger R;. Eur J Biochem 1999;263:6-13.. [2]. 9640531. SMC protein complexes and higher-order chromosome dynamics.. Hirano T;. Curr Opin Cell Biol 1998;10:317-322. (from Pfam)
chromosome segregation protein SMC
SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle.
chromosome segregation protein SMC is required for chromosome condensation and partitioning
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on