This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others. [1]. 1761222. Nucleotide sequence and transcriptional start point of the kan. gene encoding an aminoglycoside 3-N-acetyltransferase from. Streptomyces griseus SS-1198PR.. Ishikawa J, Hotta K;. Gene 1991;108:127-132.. [2]. 2060791. Characterisation of aminoglycoside acetyltransferase-encoding. genes of neomycin-producing Micromonospora chalcea and. Streptomyces fradiae.. Salauze D, Perez-Gonzalez JA, Piepersberg W, Davies J;. Gene 1991;101:143-148.. [3]. 21601576. Structural analysis of a putative aminoglycoside. N-acetyltransferase from Bacillus anthracis.. Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I,. Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD,. Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor. W;. J Mol Biol. 2011;410:411-423. (from Pfam)
GO Terms:- Molecular Function:
- aminoglycoside 3-N-acetyltransferase activity (GO:0046353)
- Biological Process:
- response to antibiotic (GO:0046677)
- Date:
- 2024-08-14