Protein Family Models

This B12 binding domain is found in methionine synthase EC:2.1.1.13 Swiss:Q99707, and other shorter proteins that bind to B12. This domain is always found to the N-terminus of Pfam:PF02310. The structure of this domain is known [1], it is a 4 helix bundle. Many of the conserved residues in this domain are involved in B12 binding, such as those in the MXXVG motif. [1]. 7992050. How a protein binds B12: A 3.0 A X-ray structure of B12-binding. domains of methionine synthase. Drennan CL, Huang S, Drummond JT, Matthews RG, Lidwig ML;. Science 1994;266:1669-1674. (from Pfam)

Date:

2024-08-14

This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2]. [1]. 9739092. How a protein prepares for B12 binding: structure and dynamics. of the B12-binding subunit of glutamate mutase from Clostridium. tetanomorphum.. Tollinger M, Konrat R, Hilbert BH, Marsh EN, Krautler B;. Structure 1998;6:1021-1033.. [2]. 11914353. Role for vitamin B(12) in light induction of gene expression in. the bacterium Myxococcus xanthus.. Cervantes M, Murillo FJ;. J Bacteriol. 2002;184:2215-2224.. [3]. 18315685. Vitamin B12 partners the CarH repressor to downregulate a. photoinducible promoter in Myxococcus xanthus.. Perez-Marin MC, Padmanabhan S, Polanco MC, Murillo FJ,. Elias-Arnanz M;. Mol Microbiol. 2008;67:804-819. (from Pfam)

Date:

2024-08-14

B12-binding domain-containing protein, similar to Methanosarcina barkeri methanol--corrinoid protein that acts as a methyl group carrier in methanogenesis in the methanol pathway

Date:

2020-09-08