Protein Family Models

This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters. [1]. 9837940. The three-dimensional structure of 4-hydroxybenzoyl-CoA. thioesterase from Pseudomonas sp. Strain CBS-3.. Benning MM, Wesenberg G, Liu R, Taylor KL, Dunaway-Mariano D,. Holden HM;. J Biol Chem 1998;273:33572-33579.. [2]. 8805534. Structure of a dehydratase-isomerase from the bacterial pathway. for biosynthesis of unsaturated fatty acids: two catalytic. activities in one active site.. Leesong M, Henderson BS, Gillig JR, Schwab JM, Smith JL;. Structure 1996;4:253-264. (from Pfam)

Date:

2024-04-03

hotdog fold domain-containing protein belonging to the hotdog fold superfamily of thioesterases and dehydratases, similar to beta-alanyl-CoA:ammonia lyase that catalyzes the deamination of beta-alanyl-CoA to reversibly form ammonia and acrylyl-CoA

Date:

2022-10-03