Protein Family Models for Protein (Select 502107927) - Protein Family Models

Select item 4304221.

Homocitrate synthase post-HMGL domain-like

Date:: 2024-08-14

Family Accession:: NF046876.1
Method:: HMM

Select item 4116602.

This family contains a diverse set of enzymes. These include various aldolases and a region of pyruvate carboxylase. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-08-14

Family Accession:: NF012885.5
Method:: HMM

Select item 4114293.

Lrp/AsnC ligand binding domain-containing protein

The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold [2]. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 7770911. The eubacterial transcriptional activator Lrp is present in the. archaeon Pyrococcus furiosus.. Kyrpides NC, Ouzounis CA;. Trends Biochem Sci 1995;20:140-141.. [2]. 17374605. The structure and transcriptional analysis of a global regulator. from Neisseria meningitidis.. Ren J, Sainsbury S, Combs SE, Capper RG, Jordan PW, Berrow NS,. Stammers DK, Saunders NJ, Owens RJ;. J Biol Chem. 2007;282:14655-14664. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF013224.5
Method:: HMM

Select item 3899644.

new record, indexing in progress

Family Accession:

Select item 3894445.

new record, indexing in progress

Family Accession:

Select item 3468696.

new record, indexing in progress

Family Accession:

Select item 3465777.

new record, indexing in progress

Family Accession:

Select item 3165748.

new record, indexing in progress

Family Accession:

Select item 3155059.

new record, indexing in progress

Family Accession:

Select item 22689010.

2-isopropylmalate synthase

2-isopropylmalate synthase converts acetyl-CoA and alpha-ketoisovalerate into alpha-isopropylmalate in the committed step of leucine biosynthesis

Date:: 2023-03-02

Family Accession:: 11479332
Method:: Sparcle

Select item 17623911.

2-isopropylmalate synthase

Date:: 2020-10-26

Family Accession:: NF002085.0
Method:: HMM

Select item 14308812.

homocitrate synthase

This model includes the yeast LYS21 gene which carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. A related pathway is found in Thermus thermophilus [1]. This enzyme is closely related to 2-isopropylmalate synthase (LeuA) and citramalate synthase (CimA), both of which are present in the euryarchaeota. Some archaea have a separate homocitrate synthase (AksA) which also synthesizes longer homocitrate analogs [2].

Gene:: lysS

GO Terms:

Molecular Function:: homocitrate synthase activity (GO:0004410)

Biological Process:: carboxylic acid metabolic process (GO:0019752)

Biological Process:: lysine biosynthetic process via aminoadipic acid (GO:0019878)

Molecular Function:: acyltransferase activity, acyl groups converted into alkyl on transfer (GO:0046912)

Date:: 2024-05-30

Family Accession:: TIGR02146.1
Method:: HMM

Select item 5438913.

new record, indexing in progress

Family Accession:

Select item 5404514.

new record, indexing in progress

Family Accession:

Select item 2800015.

new record, indexing in progress

Family Accession:

Select item 2768116.

new record, indexing in progress

Family Accession:

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