Protein Family Models

This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc. Note that some of the enzymes is this family are bifunctional such as Swiss:O35826 and Swiss:Q9Z0P6 in this instance Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of Swiss:O35826 is the kinase domain [3]. [1]. 9515923. Characterization of the gene cassette required for biosynthesis. of the (alpha1-->6)-linked N-acetyl-D-mannosamine-1-phosphate. capsule of serogroup A Neisseria meningitidis.. Swartley JS, Liu LJ, Miller YK, Martin LE, Edupuganti S,. Stephens DS;. J Bacteriol. 1998;180:1533-1539.. [2]. 9440531. Staphylococcus aureus cap5O and cap5P genes functionally. complement mutations affecting enterobacterial common-antigen. biosynthesis in Escherichia coli.. Kiser KB, Lee JC;. J Bacteriol 1998;180:403-406.. [3]. 9305888. A bifunctional enzyme catalyzes the first two steps in. N-acetylneuraminic acid biosynthesis of rat liver. Molecular. cloning and functional expression of UDP-N-acetyl-glucosamine. 2-epimerase/N-acetylmannosamine kinase.. Stasche R, Hinderlich S, Weise C, Effertz K, Lucka L, Moormann. P, Reutter W;. J Biol Chem 1997;272:24319-24324. (from Pfam)

Date:

2024-08-14

UDP-N-acetyl glucosamine 2-epimerase reversibly interconverts uridine diphosphate N-acetylglucosamine and uridine diphosphate -N-acetylmannosamine

Date:

2024-08-01