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TrbC/VirB2 family protein
TrbC is a pilin found in bacterial type IV secretion systems. The protein undergoes three processing steps before gaining its mature cyclic structure [1]. This family also contains VIRB2 type IV secretion proteins [2]. This alignment contains two predicted transmembrane helices. [1]. 12160637. Tying rings for sex.. Kalkum M, Eisenbrandt R, Lurz R, Lanka E;. Trends Microbiol 2002;10:382-387.. [2]. 12421311. The VirB/VirD4 type IV secretion system of Bartonella is. essential for establishing intraerythrocytic infection.. Schulein R, Dehio C;. Mol Microbiol 2002;46:1053-1067. (from Pfam)
TrbC/VirB2 family protein may function a major pilus subunit; similar to type IV secretion system protein PtlA, which is a component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane
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