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restriction endonuclease
Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2]. [1]. 1650347. Characterization and expression of the Escherichia coli Mrr. restriction system.. Waite-Rees PA, Keating CJ, Moran LS, Slatko BE, Hornstra LJ,. Benner JS;. J Bacteriol 1991;173:5207-5219.. [2]. 11313145. Identification of a PD-(D/E)XK-like domain with a novel. configuration of the endonuclease active site in the. methyl-directed restriction enzyme Mrr and its homologs.. Bujnicki JM, Rychlewski L;. Gene 2001;267:183-191. (from Pfam)
restriction endonuclease such as Escherichia coli Mrr restriction system protein (EcoKMrr), a type IV restriction endonuclease that recognizes and cleaves N6-methyladenine- and 5-methylcytosine-containing DNA
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