Protein Family Models

Chorismate mutase (CM) EC:5.4.99.5 catalyses the the conversion of chorismate to prephenate in the shikimate pathway of tyrosine and phenylalanine biosynthesis in bacteria, fungi and plants [1,2]. The three types of CM are AroH class, AroQ class, prokaryotic type and AroQ class, eukaryotic type. Structurally CMs can be divided into two main groups: type I (AroH) class and type II (AroQ). Type I (AroH) CMs include CMs characterised by a trimeric pseudo alpha/beta barrel structure [2]. The two types of the AroQ structural class (the Escherichia coli CM dimer and the yeast CM monomer) can be structurally superimposed, and the topology of the four-helix bundle forming the active site is conserved [3]. CMs can be monofunctional or bifunctional (generally fused to another shikimate pathway member). Despite the structural differences, all CMs perform the same basic reaction [2]. This entry represents chorismate mutases of the AroH class predominantly from Terrabacteria. [1]. 8378335. Crystal structures of the monofunctional chorismate mutase from. Bacillus subtilis and its complex with a transition state. analog.. Chook YM, Ke H, Lipscomb WN;. Proc Natl Acad Sci U S A 1993;90:8600-8603.. [2]. 17965159. The two chorismate mutases from both Mycobacterium tuberculosis. and Mycobacterium smegmatis: biochemical analysis and limited. regulation of promoter activity by aromatic amino acids.. Schneider CZ, Parish T, Basso LA, Santos DS;. J Bacteriol. 2008;190:122-134.. [3]. 11528003. Allosteric regulation of catalytic activity: Escherichia coli. aspartate transcarbamoylase versus yeast chorismate mutase.. Helmstaedt K, Krap. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

chorismate mutase catalyzes the interconversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis

Date:

2019-06-11

This model represents a family of monofunctional (non-fused) chorismate mutases from gram positive bacteria (Firmicutes) and cyanobacteria. Trusted members of the family are found in operons with other enzymes of the chorismate pathways, both up- and downstream of CM (Listeria, Bacillus, Oceanobacillus) or are the sole CM in the genome where the other members of the chorismate pathways are found elsewhere in the genome (Nostoc, Thermosynechococcus).

Gene:

aroH

Date:

2021-04-27