Protein Family Models

This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di-GMP [4,6,7], which modulates the activity of the respective protein. The structure of this domain is now known [1,2,4]. [1]. 15843017. The X-ray structure of the type II secretion system complex. formed by the N-terminal domain of EpsE and the cytoplasmic. domain of EpsL of Vibrio cholerae.. Abendroth J, Murphy P, Sandkvist M, Bagdasarian M, Hol WG;. J Mol Biol. 2005;348:845-855.. Paper describing PDB structure 2d27. [2]. 16162504. Structure and function of the XpsE N-terminal domain, an. essential component of the Xanthomonas campestris type II. secretion system.. Chen Y, Shiue SJ, Huang CW, Chang JL, Chien YL, Hu NT, Chan NL;. J Biol Chem. 2005;280:42356-42363.. [3]. 14600218. Type II protein secretion and its relationship to bacterial type. IV pili and archaeal flagella.. Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP,. Saier MH Jr;. Microbiology. 2003;149:3051-3072.. Paper describing PDB structure 5htl. [4]. 27578558. Nucleotide binding by the widespread high-affinity cyclic di-GMP. receptor MshEN domain.. Wang YC, Chin KH, Tu ZL, He J, Jones CJ, Sanchez DZ, Yildiz FH,. Galperin MY, Chou SH;. Nat Commun. 2016;7:12481.. Paper describing PDB structure 6ejf. [5]. 30232337. Structural cycle of the Thermus thermophilus PilF ATPase: the. powering of type IVa pilus assembly.. Collins R, Karuppiah V, Siebert CA, Dajani R, Thistlethwaite A,. Derrick JP;. Sci Rep. 2018. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

Members of this family include ATPases of type 2 secretion systems (T2SS), type 4 pilin (T4P, often involved in twitching motility), and type 4 secretion systems.

Date:

2024-08-14

This model describes a protein of type IV pilus biogenesis designated PilB in Pseudomonas aeruginosa but PilF in Neisseria gonorrhoeae; the more common usage, reflected here, is PilB. This protein is an ATPase involved in protein export for pilin assembly and is closely related to GspE (TIGR02533) of type II secretion, also called the main terminal branch of the general secretion pathway. Note that type IV pilus systems are often divided into type IV-A and IV-B, with the latter group including bundle-forming pilus, mannose-sensitive hemagglutinin, etc. Members of this family are found in type IV-A systems.

Gene:

pilB

Date:

2021-05-12