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Links from Protein

Items: 13

1.

1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein

This family contains 1-deoxyxylulose-5-phosphate synthase (DXP synthase), an enzyme which catalyses the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, to yield 1-deoxy-D- xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6). [1]. 9371765. Identification of a thiamin-dependent synthase in Escherichia. coli required for the formation of the 1-deoxy-D-xylulose. 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.. Sprenger GA, Schorken U, Wiegert T, Grolle S, de Graaf AA,. Taylor SV, Begley TP, Bringer-Meyer S, Sahm H;. Proc Natl Acad Sci U S A. 1997;94:12857-12862. (from Pfam)

GO Terms:
Molecular Function:
1-deoxy-D-xylulose-5-phosphate synthase activity (GO:0008661)
Biological Process:
terpenoid biosynthetic process (GO:0016114)
Date:
2024-08-14

Family Accession:
NF024688.5
Method:
HMM

2.

thiamine pyrophosphate-dependent enzyme

GO Terms:
Molecular Function:
catalytic activity (GO:0003824)
Molecular Function:
thiamine pyrophosphate binding (GO:0030976)
Date:
2024-08-14

Family Accession:
NF014794.5
Method:
HMM

3.

thiamine pyrophosphate-dependent enzyme

This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase. (from Pfam)

GO Terms:
Molecular Function:
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624)
Date:
2024-08-14

Family Accession:
NF012880.5
Method:
HMM

4.

Transketolase, thiamine diphosphate binding domain

This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis. [1]. 8176731. Refined structure of transketolase from Saccharomyces cerevisiae. at 2.0 A resolution.. Nikkola M, Lindqvist Y, Schneider G;. J Mol Biol 1994;238:387-404.. [2]. 1628611. Three-dimensional structure of transketolase, a thiamine. diphosphate dependent enzyme, at 2.5 A resolution.. Lindqvist Y, Schneider G, Ermler U, Sundstrom M;. EMBO J 1992;11:2373-2379. (from Pfam)

Date:
2024-08-14

Family Accession:
NF012670.5
Method:
HMM

5.
new record, indexing in progress
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6.
new record, indexing in progress
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7.
new record, indexing in progress
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8.
new record, indexing in progress
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9.
new record, indexing in progress
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10.
new record, indexing in progress
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11.
new record, indexing in progress
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12.
new record, indexing in progress
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13.

thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha

thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha is part of the E1 component of a multi-enzyme dehydrogenase complex such as branched-chain alpha-keto acid dehydrogenase, which catalyzes the multi-step oxidative decarboxylation of alpha-keto acids derived from the branched-chain amino-acids valine, leucine, and isoleucine

Date:
2024-08-21

Family Accession:
10787196
Method:
Sparcle

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