Protein Family Models

Date:

2023-12-12

This domain appears to be the fist transmembrane region of the SecD export protein. SecD is directly involved in protein secretion and important for the release of proteins that have been translocated across the cytoplasmic membrane. [1]. 16452406. Archaeal and bacterial SecD and SecF homologs exhibit striking. structural and functional conservation.. Hand NJ, Klein R, Laskewitz A, Pohlschroder M;. J Bacteriol. 2006;188:1251-1259.. [2]. 8428584. SecD is involved in the release of translocated secretory. proteins from the cytoplasmic membrane of Escherichia coli.. Matsuyama S, Fujita Y, Mizushima S;. EMBO J. 1993;12:265-270. (from Pfam)

Date:

2024-04-03

Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport [1]. [1]. 10694977. Analysis of the proteome of Mycobacterium tuberculosis in. silico.. Tekaia F, Gordon SV, Garnier T, Brosch R, Barrell BG, Cole ST;. Tuber Lung Dis 1999;79:329-342. (from Pfam)

Date:

2024-04-03

This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [1]. SecD and SecF are required to maintain a proton motive force [2]. [1]. 9694879. SecDF of Bacillus subtilis, a molecular Siamese twin required. for the efficient secretion of proteins.. Bolhuis A, Broekhuizen CP, Sorokin A, van Roosmalen ML, Venema. G, Bron S, Quax WJ, van Dijl JM;. J Biol Chem 1998;273:21217-21224.. [2]. 8112309. SecD and SecF are required for the proton electrochemical. gradient stimulation of preprotein translocation.. Arkowitz RA, Wickner W;. EMBO J 1994;13:954-963. (from Pfam)

Date:

2024-04-03

Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert.

Gene:

secD

Date:

2021-04-27

The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins.

Date:

2019-09-10