Protein Family Models

This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule [1]. [1]. 9826740. Characterization of a murine type II sodium-phosphate. cotransporter expressed in mammalian small intestine.. Hilfiker H, Hattenhauer O, Traebert M, Forster I, Murer H, Biber. J;. Proc Natl Acad Sci U S A 1998;95:14564-14569. (from Pfam)

Date:

2024-08-14

This HMM describes essentially the full length of an uncharacterized protein from Bacillus subtilis and correponding lengths of longer proteins from E. coli and Treponema pallidum. PSI-BLAST analysis converges to demonstrate homology to one other group of proteins, type II sodium/phosphate (Na/Pi) cotransporters. A well-conserved repeated domain in this family, approximately 60 residues in length, is also repeated in the Na/Pi cotransporters, although with greater spacing between the repeats. The two families share additional homology in the region after the first repeat, share the properly of having extensive hydrophobic regions, and may be similar in function.

Date:

2024-05-30

Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.

Date:

2024-05-02