Protein Family Models

This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation [1]. Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localising SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex [3]. SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity [2]. [1]. 10096082. A vital stain for studying membrane dynamics in bacteria: a. novel mechanism controlling septation during Bacillus subtilis. sporulation.. Pogliano J, Osborne N, Sharp MD, Abanes-De Mello A, Perez A, Sun. YL, Pogliano K;. Mol Microbiol. 1999;31:1149-1159.. [2]. 17376078. Engulfment during sporulation in Bacillus subtilis is governed. by a multi-protein complex containing tandemly acting. autolysins.. Chastanet A, Losick R;. Mol Microbiol. 2007;64:139-152.. [3]. 17824930. Dual localization pathways for the engulfment proteins during. Bacillus subtilis spor. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

Gene:

spoIIP

Date:

2021-03-11

stage II sporulation protein P is an autolysin that is involved in the engulfment of the developing spore (the forespore) by the adjacent mother cell during the conversion of a growing cell into an endospore

Date:

2019-06-26

Stage II sporulation protein P is a protein of the endospore formation program in a number of lineages in the Firmicutes (low-GC Gram-positive bacteria). It is expressed in the mother cell compartment, under control of Sigma-E. SpoIIP, along with SpoIIM and SpoIID, is one of three major proteins involved in engulfment of the forespore by the mother cell. This protein family is named for the single member in Bacillus subtilis, although most sporulating bacteria have two members.

Gene:

spoIIP

Date:

2023-10-17