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non-canonical purine NTP pyrophosphatase
This family consists of the HAM1 protein Swiss:P47119 and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae Swiss:P47119 [1]. The HAM1 protein protects the cell from HAP, either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions [1]. [1]. 8789257. HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity. and mutagenesis in the yeast Saccharomyces cerevisiae.. Noskov VN, Staak K, Shcherbakova PV, Kozmin SG, Negishi K, Ono. BC, Hayatsu H, Pavlov YI;. Yeast 1996;12:17-29. (from Pfam)
RdgB/HAM1 family pyrophosphatase that hydrolyzes non-canonical purine nucleotides to their respective monophosphates and prevents their incorporation into DNA
RdgB/HAM1 family non-canonical purine NTP pyrophosphatase
Saccharomyces cerevisiae HAM1 protects against the mutagenic effects of the base analog 6-N-hydroxylaminopurine, which can be a natural product of monooxygenase activity on adenine. Methanococcus jannaschii MJ0226 and E. coli RdgB are also characterized as pyrophosphatases active against non-standard purines NTPs. E. coli RdgB appears to act by intercepting non-canonical deoxyribonucleotide triphosphates from replication precursor pools.[3]
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