Protein Family Models

This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases. [1]. 10373108. Structure of the Escherichia coli fumarate reductase respiratory. complex.. Iverson TM, Luna-Chavez C, Cecchini G, Rees DC;. Science 1999;284:1961-1966. (from Pfam)

Date:

2024-08-14

This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase. [1]. 8061609. Structure of glutathione reductase from Escherichia coli at 1.86. A resolution: comparison with the enzyme from human. erythrocytes.. Mittl PR, Schulz GE. Protein Sci 1994;3:799-809. (from Pfam)

Date:

2024-08-14

Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol

Date:

2020-10-26

This HMM represents the succinate dehydrogenase flavoprotein subunit as found in the low-GC Gram-positive bacteria and a few other lineages. This enzyme may act in a complete or partial TCA cycle, or act in the opposite direction as fumarate reductase. In some but not all species, succinate dehydrogenase and fumarate reductase may be encoded as separate isozymes.

Gene:

sdhA

Date:

2019-12-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit similar to Bacteroides fragilis fumarate reductase flavoprotein subunit that is important for both energy metabolism and succinate biosynthesis

Date:

2018-05-04