Protein Family Models for Protein (Select 763115233) - Protein Family Models

Select item 4042901.

TAXI family TRAP transporter solute-binding subunit

Date:: 2023-12-12

Family Accession:: NF028178.4
Method:: HMM

Select item 3960172.

ABC transporter substrate-binding protein

This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine [1][2][3]. They are regulated by thiamine [2]. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor [4]. [1]. 12271461. Functional analysis of yeast gene families involved in. metabolism of vitamins B1 and B6.. Rodriguez-Navarro S, Llorente B, Rodriguez-Manzaneque MT, Ramne. A, Uber G, Marchesan D, Dujon B, Herrero E, Sunnerhagen P,. Perez-Ortin JE;. Yeast. 2002;19:1261-1276.. [2]. 2358444. nmt1 of fission yeast. A highly transcribed gene completely. repressed by thiamine.. Maundrell K;. J Biol Chem. 1990;265:10857-10864.. [3]. 12777485. The THI5 gene family of Saccharomyces cerevisiae: distribution. of homologues among the hemiascomycetes and functional. redundancy in the aerobic biosynthesis of thiamin from. pyridoxine.. Wightman R, Meacock PA;. Microbiology. 2003;149:1447-1460.. [4]. 23048037. The last piece in the vitamin B1 biosynthesis puzzle: structural. and functional insight into yeast. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P). synthase.. Coquille S, Roux C, Fitzpatrick TB, Thore S;. J Biol Chem. 2012;287:42333-42343. (from Pfam)

Date:: 2024-04-03

Family Accession:: NF020650.4
Method:: HMM

Select item 3637963.

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Family Accession:

Select item 3583674.

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Family Accession:

Select item 3333965.

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Family Accession:

Select item 3222476.

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Family Accession:

Select item 1939577.

TAXI family TRAP transporter solute-binding subunit

TAXI family TRAP transporter solute-binding subunit functions as the receptor subunit of a Tripartite ATP-independent Periplasmic (TRAP) transporter complex

Date:: 2019-06-17

Family Accession:: 10194373
Method:: Sparcle

Select item 1813458.

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Family Accession:

Select item 1812379.

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Family Accession:

Select item 16530210.

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Family Accession:

Select item 16509511.

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Family Accession:

Select item 14308212.

TAXI family TRAP transporter solute-binding subunit

This family is one of at least three major families of extracytoplasmic solute receptor (ESR) for TRAP (Tripartite ATP-independent Periplasmic Transporter) transporters. The others are the DctP (TIGR00787) and SmoM (PF03480) families. These transporters are secondary (driven by an ion gradient) but composed of three polypeptides, although in some species the 4-TM and 12-TM integral membrane proteins are fused. Substrates for this transporter family are not fully characterized but, besides C4 dicarboxylates, may include mannitol and other compounds.

GO Terms:

Molecular Function:: transporter activity (GO:0005215)

Biological Process:: transport (GO:0006810)

Date:: 2021-04-27

Family Accession:: TIGR02122.1
Method:: HMM

Select item 2601413.

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Family Accession:

Select item 2509314.

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Family Accession:

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