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copper transporter
Outer membrane channel protein MctB in Mycobacterium tuberculosis is part of a Cu resistance mechanism that ensures low intracellular Cu levels in the bacterium. Human resistance to bacteria, mediated via IFN-gamma-mediated activation of macrophages, may involve the use of reactive Cu(1) in the presence of hydrogen peroxide, since activated Cu is toxic to bacteria. IFN-gamma stimulates the trafficking of the Cu transporter ATP7a to the vesicles that fuse with phagosome and these phagosomes are found to have a high Cu content and an increased bactericidal activity against E.coli. Using MctB, Mycobacterium tuberculosis may limit the amount of excess Cu within it whole in the host [1]. [1]. 21205886. Copper resistance is essential for virulence of Mycobacterium. tuberculosis.. Wolschendorf F, Ackart D, Shrestha TB, Hascall-Dove L, Nolan S,. Lamichhane G, Wang Y, Bossmann SH, Basaraba RJ, Niederweis M;. Proc Natl Acad Sci U S A. 2011;108:1621-1626. (from Pfam)
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