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type I 3-dehydroquinate dehydratase
Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase.) Catalyses the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate giving dehydroshikimate. Dehydroquinase functions in the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Type II 3-dehydroquinase catalyses the trans-dehydration of 3-dehydroshikimate see Pfam:PF01220. [1]. 10360352. The two types of 3-dehydroquinase have distinct structures but. catalyze the same overall reaction.. Gourley DG, Shrive AK, Polikarpov I, Krell T, Coggins JR,. Hawkins AR, Isaacs NW, Sawyer L;. Nat Struct Biol 1999;6:521-525.. Discusses the pentafunctional AROM multi-domain protein, which. possesses a Type I 3-dehydroquinase enzyme. The AROM protein. catalyses steps two to six in the shikimate pathway in many. microbial eukaryotes.. [2]. 7556173. The molecular biology of multidomain proteins. Selected. examples.. Hawkins AR, Lamb HK;. Eur J Biochem 1995;232:7-18. (from Pfam)
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