Protein Family Models

FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria [1]. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction [1]. FtsK can be split into three domains called alpha (this entry), beta and gamma. The alpha and beta domains contain the core ATPase machinery of the DNA translocase [1]. [1]. 16916635. Double-stranded DNA translocation: structure and mechanism of. hexameric FtsK.. Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J;. Mol Cell. 2006;23:457-469. (from Pfam)

Date:

2024-08-14

4TM_FtsK is the integral membrane domain of the FtsK DNA tranlocases. During sporulation in Bacillus subtilis, the SpoIIIE protein is believed to form a translocation pore at the leading edge of the nearly closed septum. The E. coli FtsK protein is homologous to SpoIIIE, and can free chromosomes trapped in vegetative septa. [1]. 16916635. Double-stranded DNA translocation: structure and mechanism of. hexameric FtsK.. Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J;. Mol Cell. 2006;23:457-469.. [2]. 17057717. The FtsK gamma domain directs oriented DNA translocation by. interacting with KOPS.. Sivanathan V, Allen MD, de Bekker C, Baker R, Arciszewska LK,. Freund SM, Bycroft M, Lowe J, Sherratt DJ;. Nat Struct Mol Biol. 2006;13:965-972.. [3]. 18722176. Molecular mechanism of sequence-directed DNA loading and. translocation by FtsK.. Lowe J, Ellonen A, Allen MD, Atkinson C, Sherratt DJ, Grainge I;. Mol Cell. 2008;31:498-509. (from Pfam)

Date:

2024-08-14

This domain directs oriented DNA translocation and forms a winged helix structure [1]. Mutated proteins with substitutions in the FtsK gamma DNA-recognition helix are impaired in DNA binding [1]. [1]. 17057717. The FtsK gamma domain directs oriented DNA translocation by. interacting with KOPS.. Sivanathan V, Allen MD, de Bekker C, Baker R, Arciszewska LK,. Freund SM, Bycroft M, Lowe J, Sherratt DJ;. Nat Struct Mol Biol. 2006;13:965-972. (from Pfam)

Date:

2024-08-14

FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids [1], termed the FtsK/SpoIIIE family. This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli Swiss:P46889 and the stage III sporulation protein E SpoIIIE Swiss:P21458 which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification [1]. The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer [1]. [1]. 7592387. A new Escherichia coli cell division gene, ftsK.. Begg KJ, Dewar SJ, Donachie WD;. J Bacteriol 1995;177:6211-6222.. [2]. 8160014. Bacillus subtilis spoIIIE protein required for DNA segregation. during asymmetric cell division.. Wu LJ ,Errington J;. Science 1994;264:572-575. (from Pfam)

Date:

2024-08-14

DNA translocase FtsK is a motor that converts the chemical energy of binding and hydrolyzing ATP into movement of the double-stranded DNA substrate

Date:

2022-08-18