Protein Family Models for Protein (Select 919593888) - Protein Family Models

Select item 4257871.

helix-hairpin-helix domain-containing protein

Date:: 2024-08-14

Family Accession:: NF025873.5
Method:: HMM

Select item 4237282.

helix-hairpin-helix domain-containing protein

The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain [2]. [1]. 8692686. The helix-hairpin-helix DNA-binding motif: a structural basis. for non-sequence-specific recognition of DNA.. Doherty AJ, Serpell LC, Ponting CP;. Nucleic Acids Res 1996;24:2488-2497.. [2]. 18439896. Structural biochemistry of a bacterial checkpoint protein. reveals diadenylate cyclase activity regulated by DNA. recombination intermediates.. Witte G, Hartung S, Buttner K, Hopfner KP;. Mol Cell. 2008;30:167-178. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024235.5
Method:: HMM

Select item 4133593.

ERCC4 domain-containing protein

This domain is a family of nucleases. The family includes EME1 which is an essential component of a Holliday junction resolvase [2-3]. EME1 interacts with MUS81 to form a DNA structure-specific endonuclease. [2]. 14527419. The endogenous Mus81-Eme1 complex resolves Holliday junctions by. a nick and counternick mechanism.. Gaillard PH, Noguchi E, Shanahan P, Russell P;. Mol Cell. 2003;12:747-759.. [3]. 11719193. Mus81-Eme1 are essential components of a Holliday junction. resolvase.. Boddy MN, Gaillard PH, McDonald WH, Shanahan P, Yates JR 3rd,. Russell P;. Cell. 2001;107:537-548.. [3]. 22638584. Sequence, structure and functional diversity of PD-(D/E)XK. phosphodiesterase superfamily.. Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski. K;. Nucleic Acids Res. 2012;40:7016-7045. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: nuclease activity (GO:0004518)

Date:: 2024-08-14

Family Accession:: NF014752.5
Method:: HMM

Select item 4048384.