Protein Family Models for Protein (Select 974590317) - Protein Family Models

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Items: 5

Select item 4165621.

tRNA (Uracil-5-)-methyltransferase

This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalysed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity [1]. [1]. 12003492. Dual function of the tRNA(m(5)U54)methyltransferase in tRNA. maturation.. Johansson MJ, Bystrom AS;. RNA 2002;8:324-335. (from Pfam)

GO Terms:

Biological Process:: RNA processing (GO:0006396)

Molecular Function:: RNA methyltransferase activity (GO:0008173)

Date:: 2024-08-14

Family Accession:: NF017743.5
Method:: HMM

Select item 3937362.

new record, indexing in progress

Family Accession:

Select item 3512103.

new record, indexing in progress

Family Accession:

Select item 2267204.

tRNA (uridine(54)-C5)-methyltransferase TrmA

tRNA (uridine(54)-C5)-methyltransferase TrmA is a dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA

Date:: 2023-03-13

Family Accession:: 11480328
Method:: Sparcle

Select item 1435955.

tRNA (uridine(54)-C5)-methyltransferase TrmA

Catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs. The seed alignment derived from PF05958 in Pfam 12.0, but cutoffs were tuned to select only TrmA. Homologous proteins excluded by this model include other uracil methyltransferases, such as RumA, active on rRNA.