Brain metastasis as first manifestation of ovarian cancer

Eur J Obstet Gynecol Reprod Biol. 1999 Jan;82(1):81-3. doi: 10.1016/s0301-2115(98)00160-2.

Abstract

Brain metastasis from ovarian cancer, a rare and highly dismal event, develops mostly during or after postoperative chemotherapy. This report documents the clinical findings and magnetic resonance imaging of an uncommon case who presented signs of increased intracranial pressure as a first manifestation. Histologic examination of removed brain lesion demonstrated ovarian origin, while no evidence of a locally invasive lesion was found at exploratory laparotomy ('tentative' surgical stage Ia). The possibility of ovarian origin should be always considered in a woman with brain involvement.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Brain Neoplasms / physiopathology
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / therapy
  • Carcinoma, Endometrioid / diagnosis
  • Carcinoma, Endometrioid / secondary*
  • Carcinoma, Endometrioid / surgery
  • Cisplatin / administration & dosage
  • Craniotomy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Glycerol / therapeutic use
  • Headache / drug therapy
  • Headache / surgery
  • Humans
  • Hysterectomy
  • Intracranial Hypertension / etiology
  • Laparotomy
  • Magnetic Resonance Imaging
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery
  • Ovary / diagnostic imaging
  • Pharmaceutical Vehicles / therapeutic use
  • Prednisolone / therapeutic use
  • Ultrasonography

Substances

  • Pharmaceutical Vehicles
  • Doxorubicin
  • Cyclophosphamide
  • Prednisolone
  • Glycerol
  • Cisplatin