Abstract
Virus-associated hemophagocytic syndrome (VAHS) is characterized by histiocytic proliferation and phagocytosis triggered by virus infections. Viruses in the herpes group, especially the Epstein-Barr virus (EBV), are well known to cause VAHS; however, the relationship between this syndrome and human herpesvirus-6 (HHV-6) infection has rarely been reported. In this study, we describe a 23-month-old girl who exhibited typical manifestations of VAHS associated with HHV-6 infection. To the best of our knowledge, this case is the fifth reported case in the English literature.
MeSH terms
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Antibodies, Viral / blood
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Blood Coagulation Disorders / etiology
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DNA, Viral / blood
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Exanthema / etiology
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Female
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Fever / etiology
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Hepatomegaly / etiology
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Herpesviridae Infections / blood
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Herpesviridae Infections / complications*
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Herpesviridae Infections / diagnosis
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Herpesvirus 6, Human / immunology
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Herpesvirus 6, Human / isolation & purification
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Herpesvirus 6, Human / pathogenicity*
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Histiocytosis, Non-Langerhans-Cell / complications
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Histiocytosis, Non-Langerhans-Cell / diagnosis
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Histiocytosis, Non-Langerhans-Cell / etiology*
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Humans
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Immunoglobulin M / blood
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Infant
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Pancytopenia / etiology
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Skull Fractures / complications
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Splenomegaly / etiology
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Viremia / complications*
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Viremia / diagnosis
Substances
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Antibodies, Viral
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DNA, Viral
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Immunoglobulin M