Human herpesvirus-6 (HHV-6)-associated hemophagocytic syndrome

Pediatr Hematol Oncol. 1996 Sep-Oct;13(5):451-6. doi: 10.3109/08880019609030857.

Abstract

Virus-associated hemophagocytic syndrome (VAHS) is characterized by histiocytic proliferation and phagocytosis triggered by virus infections. Viruses in the herpes group, especially the Epstein-Barr virus (EBV), are well known to cause VAHS; however, the relationship between this syndrome and human herpesvirus-6 (HHV-6) infection has rarely been reported. In this study, we describe a 23-month-old girl who exhibited typical manifestations of VAHS associated with HHV-6 infection. To the best of our knowledge, this case is the fifth reported case in the English literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antibodies, Viral / blood
  • Blood Coagulation Disorders / etiology
  • DNA, Viral / blood
  • Exanthema / etiology
  • Female
  • Fever / etiology
  • Hepatomegaly / etiology
  • Herpesviridae Infections / blood
  • Herpesviridae Infections / complications*
  • Herpesviridae Infections / diagnosis
  • Herpesvirus 6, Human / immunology
  • Herpesvirus 6, Human / isolation & purification
  • Herpesvirus 6, Human / pathogenicity*
  • Histiocytosis, Non-Langerhans-Cell / complications
  • Histiocytosis, Non-Langerhans-Cell / diagnosis
  • Histiocytosis, Non-Langerhans-Cell / etiology*
  • Humans
  • Immunoglobulin M / blood
  • Infant
  • Pancytopenia / etiology
  • Skull Fractures / complications
  • Splenomegaly / etiology
  • Viremia / complications*
  • Viremia / diagnosis

Substances

  • Antibodies, Viral
  • DNA, Viral
  • Immunoglobulin M