LIS1-no more no less

Mol Psychiatry. 2002;7(1):12-6. doi: 10.1038/sj.mp.4000975.

Abstract

LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the brain developmental phenotype observed in mice heterozygote for an N-terminal truncated LIS1 protein in view of known LIS1 protein interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Alleles
  • Animals
  • Brain / abnormalities*
  • Brain / embryology
  • Conserved Sequence
  • Doublecortin Domain Proteins
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics
  • Dyneins / metabolism
  • Fungal Proteins / metabolism
  • Gene Dosage
  • Genes, Lethal
  • Heterozygote
  • Humans
  • Infant, Newborn
  • Macromolecular Substances
  • Mice
  • Microtubule-Associated Proteins / deficiency
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / physiology*
  • Microtubules / metabolism
  • Microtubules / ultrastructure
  • Morphogenesis / genetics
  • Nerve Tissue Proteins / deficiency
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology*
  • Neuropeptides / deficiency
  • Neuropeptides / genetics
  • Neuropeptides / physiology
  • Oocytes / metabolism
  • Phenotype
  • Phospholipases A / chemistry
  • Phospholipases A / metabolism
  • Sequence Deletion
  • Serine Endopeptidases / metabolism
  • Xenopus laevis / embryology
  • Xenopus laevis / genetics

Substances

  • Doublecortin Domain Proteins
  • Drosophila Proteins
  • Fungal Proteins
  • Lis-1 protein, Drosophila
  • Macromolecular Substances
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • Neuropeptides
  • RO-11 protein, Neurospora crassa
  • Phospholipases A
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • PAFAH1B1 protein, human
  • Pafah1b1 protein, mouse
  • Serine Endopeptidases
  • Dyneins