Anti-Ku antibody-positive scleroderma-dermatomyositis overlap syndrome developing Graves' disease and immune thrombocytopenic purpura

Nozomu Kamei; Kiminori Yamane; Yasuyo Yamashita; Shuhei Nakanishi; Hiroshi Watanabe; Rumi Fujikawa; Keiko Hiyama; Shinichi Ishioka; Ciro Mendoza; Nobuoki Kohno

doi:10.2169/internalmedicine.41.1199

Anti-Ku antibody-positive scleroderma-dermatomyositis overlap syndrome developing Graves' disease and immune thrombocytopenic purpura

Intern Med. 2002 Dec;41(12):1199-203. doi: 10.2169/internalmedicine.41.1199.

Authors

Nozomu Kamei¹, Kiminori Yamane, Yasuyo Yamashita, Shuhei Nakanishi, Hiroshi Watanabe, Rumi Fujikawa, Keiko Hiyama, Shinichi Ishioka, Ciro Mendoza, Nobuoki Kohno

Affiliation

¹ Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima.

PMID: 12521216
DOI: 10.2169/internalmedicine.41.1199

Abstract

Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose gamma-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases.

Publication types

Case Reports

MeSH terms

Adult
Anti-Inflammatory Agents / therapeutic use
Antigens, Nuclear / immunology*
Antithyroid Agents / therapeutic use
Autoantibodies / blood*
DNA Helicases*
DNA-Binding Proteins / immunology*
Dermatomyositis / complications*
Dermatomyositis / drug therapy
Dermatomyositis / immunology
Female
Graves Disease / complications*
Graves Disease / drug therapy
Graves Disease / immunology
Humans
Ku Autoantigen
Methimazole / therapeutic use
Platelet Transfusion
Propylthiouracil / therapeutic use
Purpura, Thrombocytopenic, Idiopathic / complications*
Purpura, Thrombocytopenic, Idiopathic / immunology
Purpura, Thrombocytopenic, Idiopathic / therapy
Scleroderma, Systemic / complications*
Scleroderma, Systemic / drug therapy
Scleroderma, Systemic / immunology
Steroids

Substances

Anti-Inflammatory Agents
Antigens, Nuclear
Antithyroid Agents
Autoantibodies
DNA-Binding Proteins
Steroids
Methimazole
Propylthiouracil
DNA Helicases
XRCC5 protein, human
Xrcc6 protein, human
Ku Autoantigen