Hydroxyurea-induced dermatomyositis-like eruption

Michael J Dacey; Jeffrey P Callen

doi:10.1067/mjd.2003.74

Hydroxyurea-induced dermatomyositis-like eruption

J Am Acad Dermatol. 2003 Mar;48(3):439-41. doi: 10.1067/mjd.2003.74.

Authors

Michael J Dacey¹, Jeffrey P Callen

Affiliation

¹ Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Kentucky, USA.

PMID: 12637927
DOI: 10.1067/mjd.2003.74

Abstract

Hydroxyurea is a cytotoxic chemotherapeutic agent used for myelodysplasia. The adverse cutaneous effects due to hydroxyurea include leg ulcers, hyperpigmentation of the skin and nails, a lichen planus-like eruption, lupus erythematosus, and a dermatomyositis-like eruption. We present a case of hydroxyurea-induced dermatomyositis-like eruption and review the features of this entity as previously reported.

Publication types

Case Reports
Review

MeSH terms

Aged
Biopsy, Needle
Dermatomyositis / chemically induced*
Dermatomyositis / pathology*
Drug Eruptions / etiology
Drug Eruptions / pathology*
Female
Follow-Up Studies
Hand Dermatoses / chemically induced*
Hand Dermatoses / pathology
Humans
Immunohistochemistry
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
Risk Assessment