Signal transduction of bone morphogenetic protein receptors

Anja Nohe; Eleonora Keating; Petra Knaus; Nils O Petersen

doi:10.1016/j.cellsig.2003.08.011

Signal transduction of bone morphogenetic protein receptors

Cell Signal. 2004 Mar;16(3):291-9. doi: 10.1016/j.cellsig.2003.08.011.

Authors

Anja Nohe¹, Eleonora Keating, Petra Knaus, Nils O Petersen

Affiliation

¹ Department of Chemistry, University of Western Ontario, N6A1B7 London, Canada. anohe@uwo.ca

PMID: 14687659
DOI: 10.1016/j.cellsig.2003.08.011

Abstract

Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways.

Publication types

Review

MeSH terms

Adaptor Proteins, Signal Transducing*
Animals
Bone Morphogenetic Protein Receptors
Carrier Proteins / metabolism
DNA-Binding Proteins / metabolism
Feedback, Physiological
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases / metabolism
Models, Biological
Receptors, Growth Factor / metabolism*
Signal Transduction*
Smad Proteins
Trans-Activators / metabolism
p38 Mitogen-Activated Protein Kinases

Substances

Adaptor Proteins, Signal Transducing
Carrier Proteins
DNA-Binding Proteins
Receptors, Growth Factor
Smad Proteins
TAB2 protein, human
Trans-Activators
Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
Bone Morphogenetic Protein Receptors