Primary central nervous system lymphoma in a renal transplant recipient with Bardet-Biedl syndrome

Transplant Proc. 2005 Dec;37(10):4323-5. doi: 10.1016/j.transproceed.2005.10.121.

Abstract

Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder. End-stage renal failure has been reported as the most frequent cause of death in this disorder. There are few reports of kidney transplantation in these patients. Renal transplant patients are known to be at increased risk for the development of malignancies. Although a few patients with BBS have been described to develop malignant disease, there was no previous association with lymphoma. We report a 20-year-old patient in whom primary central nervous system lymphoma was diagnosed 20 months after renal transplantation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use
  • Bardet-Biedl Syndrome / complications*
  • Central Nervous System Neoplasms / diagnosis*
  • Central Nervous System Neoplasms / drug therapy
  • Central Nervous System Neoplasms / pathology
  • Central Nervous System Neoplasms / radiotherapy
  • Combined Modality Therapy
  • Creatinine / blood
  • Female
  • Humans
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Lymphoma / diagnosis*
  • Lymphoma / drug therapy
  • Lymphoma / pathology
  • Lymphoma / radiotherapy
  • Methotrexate / therapeutic use
  • Postoperative Complications / diagnosis

Substances

  • Antineoplastic Agents
  • Creatinine
  • Methotrexate