Transcriptome analysis of rat kidney cells continuously exposed to cadmium using DNA microarray

Ken-ichi Ohba; Youhei Okawa; Yuki Matsumoto; Yasuhiro Nakamura; Hisayoshi Ohta

doi:10.2131/jts.32.103

Transcriptome analysis of rat kidney cells continuously exposed to cadmium using DNA microarray

J Toxicol Sci. 2007 Feb;32(1):103-5. doi: 10.2131/jts.32.103.

Authors

Ken-ichi Ohba¹, Youhei Okawa, Yuki Matsumoto, Yasuhiro Nakamura, Hisayoshi Ohta

Affiliation

¹ Department of Health Administration, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. kohba@kitasato-u.ac.jp

PMID: 17327699
DOI: 10.2131/jts.32.103

Abstract

To examine the transcriptional responses of rat kidney cells continuously exposed to cadmium, we performed DNA microarray analysis. Cadmium increased levels of expression of 27 genes, including genes for Mt1, Mt2, GSTa3 and B2m and reduced those of 4 genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cadmium / toxicity*
Female
Kidney / cytology*
Kidney / drug effects*
Oligonucleotide Array Sequence Analysis
Rats
Rats, Wistar
Transcription, Genetic / drug effects*

Substances

Cadmium