Dysgerminoma in a child with ataxia-telangiectasia

Pediatr Hematol Oncol. 2007 Sep;24(6):431-6. doi: 10.1080/08880010701451434.

Abstract

Ataxia-telangiectasia is an autosomal recessive disease characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, high incidence of cancer, and increased sensitivity to ionizing radiation. The authors report a case of dysgerminoma in a child with high alpha-fetoprotein, CA125 and beta-human chorionic gonadotropin, who has been followed-up for ataxia-telangiectasia for 2 years.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Ataxia Telangiectasia / blood
  • Ataxia Telangiectasia / complications*
  • Ataxia Telangiectasia / therapy
  • Biomarkers, Tumor / blood
  • Bleomycin / administration & dosage
  • Bleomycin / adverse effects
  • CA-125 Antigen / blood
  • Carboplatin / administration & dosage
  • Child
  • Chorionic Gonadotropin, beta Subunit, Human / blood
  • Dysgerminoma / drug therapy
  • Dysgerminoma / etiology*
  • Dysgerminoma / surgery
  • Etoposide / administration & dosage
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Neoplasm Proteins / blood
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / etiology*
  • Ovarian Neoplasms / surgery
  • Ovariectomy
  • Respiration Disorders / chemically induced
  • alpha-Fetoproteins / analysis

Substances

  • Biomarkers, Tumor
  • CA-125 Antigen
  • Chorionic Gonadotropin, beta Subunit, Human
  • Immunoglobulins, Intravenous
  • Neoplasm Proteins
  • alpha-Fetoproteins
  • Bleomycin
  • Etoposide
  • Carboplatin