Disorders of neutrophil function: an overview

Methods Mol Biol. 2007:412:489-504. doi: 10.1007/978-1-59745-467-4_30.

Abstract

Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include leukocyte adhesion deficiencies, actin defects, and other disorders of chemotaxis; hyperimmunoglobulin E syndrome; Chédiak-Higashi syndrome; neutrophil specific granule deficiency; chronic granulomatous disease; and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.

Publication types

  • Review

MeSH terms

  • Cell Adhesion / genetics
  • Cell Adhesion / physiology
  • Chediak-Higashi Syndrome / etiology
  • Chemotaxis, Leukocyte / genetics
  • Chemotaxis, Leukocyte / physiology
  • Cytoplasmic Granules / metabolism
  • Glucosephosphate Dehydrogenase / genetics
  • Humans
  • Leukocyte Disorders / genetics
  • Leukocyte Disorders / physiopathology*
  • Leukocyte-Adhesion Deficiency Syndrome / etiology
  • Leukocyte-Adhesion Deficiency Syndrome / genetics
  • Models, Biological
  • Neutrophils / enzymology
  • Neutrophils / metabolism
  • Neutrophils / physiology*
  • Oxidative Stress / genetics
  • Peroxidase / deficiency
  • Peroxidase / genetics
  • RAC2 GTP-Binding Protein
  • rac GTP-Binding Proteins / genetics

Substances

  • Glucosephosphate Dehydrogenase
  • Peroxidase
  • rac GTP-Binding Proteins