Mucoepidermoid carcinoma of the submandibular gland after chemotherapy in a child

Auris Nasus Larynx. 2009 Apr;36(2):244-6. doi: 10.1016/j.anl.2008.05.003. Epub 2008 Jul 7.

Abstract

Second malignant neoplasms (SMNs) have become a concern in survivors of childhood malignancy. Although there are many reports describing SMN in patients treated for childhood cancer, salivary gland tumors rarely appear in these reports. Radiotherapy is a well-known risk factor for the development of secondary salivary gland malignancies after the treatment of childhood cancer. However, it is not well known whether chemotherapy itself treatment increases the risk of salivary gland malignancies. We report a child case with mucoepidermoid carcinoma of the submandibular gland as a SMN after chemotherapy alone for acute myeloid leukemia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy
  • Busulfan / adverse effects
  • Busulfan / therapeutic use
  • Carcinoma, Mucoepidermoid / chemically induced*
  • Carcinoma, Mucoepidermoid / pathology
  • Carcinoma, Mucoepidermoid / surgery
  • Child
  • Child, Preschool
  • Cyclophosphamide / adverse effects
  • Cyclophosphamide / therapeutic use
  • Cytarabine / adverse effects
  • Cytarabine / therapeutic use
  • Daunorubicin / adverse effects
  • Daunorubicin / therapeutic use
  • Dexamethasone / adverse effects
  • Dexamethasone / therapeutic use
  • Disease-Free Survival
  • Etoposide / adverse effects
  • Etoposide / therapeutic use
  • Follow-Up Studies
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Image Processing, Computer-Assisted
  • Leukemia, Myeloid, Acute / drug therapy*
  • Male
  • Neck Dissection
  • Neoplasms, Second Primary / chemically induced*
  • Neoplasms, Second Primary / pathology
  • Neoplasms, Second Primary / surgery
  • Positron-Emission Tomography
  • Submandibular Gland Neoplasms / chemically induced*
  • Submandibular Gland Neoplasms / pathology
  • Submandibular Gland Neoplasms / surgery
  • Thioguanine / adverse effects
  • Thioguanine / therapeutic use
  • Tomography, X-Ray Computed
  • Transplantation Conditioning

Substances

  • Cytarabine
  • Etoposide
  • Dexamethasone
  • Cyclophosphamide
  • Thioguanine
  • Busulfan
  • Daunorubicin

Supplementary concepts

  • DCTER protocol