Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool

Antimicrob Agents Chemother. 2008 Nov;52(11):4198-202. doi: 10.1128/AAC.00107-08. Epub 2008 Aug 25.

Abstract

bla(CTX-M) genes, particularly bla(CTX-M-15), are the dominant extended-spectrum beta-lactamase (ESBL) genes among clinical isolates of Escherichia coli and Klebsiella pneumoniae in Sydney, Australia, where we also found one example of bla(CTX-M-62), encoding a novel enzyme conferring ceftazidime resistance. ESBL genes were present in diverse community isolates and in a variety of associated conjugative plasmids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Conjugation, Genetic
  • Drug Resistance, Bacterial / genetics
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / microbiology
  • Genes, Bacterial*
  • Humans
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / isolation & purification
  • Molecular Sequence Data
  • New South Wales
  • Plasmids / genetics
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases

Associated data

  • GENBANK/EF219134
  • GENBANK/EU418908
  • GENBANK/EU418909
  • GENBANK/EU418910
  • GENBANK/EU418911
  • GENBANK/EU418912
  • GENBANK/EU418913
  • GENBANK/EU418914
  • GENBANK/EU418915
  • GENBANK/EU418916
  • GENBANK/EU418917
  • GENBANK/EU418918
  • GENBANK/EU418919
  • GENBANK/EU418920