Abstract
In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomycin C in strains with an intact lexA gene.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Base Sequence
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial / genetics*
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Escherichia coli Proteins / genetics*
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Gene Expression / genetics
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Gene Expression / physiology*
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Mitomycin / pharmacology
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Molecular Sequence Data
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Nucleic Acid Synthesis Inhibitors / pharmacology
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Plasmids / genetics
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Quinolones / pharmacology*
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Reverse Transcriptase Polymerase Chain Reaction
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SOS Response, Genetics / genetics*
Substances
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DNA, Bacterial
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Escherichia coli Proteins
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Nucleic Acid Synthesis Inhibitors
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Qnr protein, E coli
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Quinolones
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Mitomycin